Biosynthesis of bioactive microbial metabolites and its application to the structural studies and production of hybrid compounds.

II. Structure Elucidation on Polyketide Antibiotics by Biosynthetic Means A. Elasnin B. Herbimycin C. Irumamycin D. Phthoramycin E. Aurantinin F. Xanthoquinodin III. Biosynthesis and Stereochemistry of Macrolide Antibiotics and Production of New Hybrid Macrolides and Polyketide A. Biosynthesis of the Aglycone Moiety in 16-Membered Macrolides, Leucomycins and Tylosin B. The Intact Incorporation of a Chain-elongation Intermediate into Macrolides C. Biosynthesis of 16-MemberedMacrolides after the Formation of the Lactone Ring D. Stereochemistry of Tylosin and Its Related Compounds by Microbial Conversion E. Production of Hybrid Macrolides by Microbial Transformation F. Production of a New Hybrid Antibiotic, Mederrohdin by Genetic Manipulation